Talking Sleep

Predicting RBD Phenoconversion via Autonomic Reflex Testing

16 snips
Jul 25, 2025
Dr. Luca Baldelli, a neurologist from the University of Bologna and Treasurer-Elect of the International REM Sleep Behavior Disorder Study Group, sheds light on groundbreaking research in predicting neurodegenerative diseases among RBD patients. He discusses how simple autonomic reflex tests can identify those at higher risk for conditions like Parkinson's disease. The conversation highlights the significance of monitoring cardiovascular autonomic dysfunction and explores practical applications for clinicians in managing RBD, potentially transforming patient prognoses.
Ask episode
AI Snips
Chapters
Transcript
Episode notes
INSIGHT

Autonomic Dysfunction in RBD

  • Autonomic dysfunction in RBD mainly involves cardiovascular autonomic failure, evidenced by neurogenic orthostatic hypotension.
  • This reflects the autonomic nervous system's failure to respond properly to positional blood pressure changes.
ADVICE

Measure Orthostatic Hypotension Objectively

  • Measure standing blood pressure and heart rate after 3 minutes to detect orthostatic hypotension in RBD patients.
  • Objective autonomic testing is crucial as many patients do not recognize or report symptoms.
ADVICE

Autonomic Reflex Testing Protocol

  • Use autonomic reflex testing with tilt table and maneuvers like Valsalva and deep breathing for thorough autonomic function assessment.
  • This evaluates both sympathetic and parasympathetic branches, not just blood pressure drops.
Get the Snipd Podcast app to discover more snips from this episode
Get the app