Mastering Nutrition

What to Do About Your COMT Genes | Chris Masterjohn Lite #42

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Jan 16, 2018
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INSIGHT

COMT's Role

  • COMT, an enzyme, uses methyl groups to methylate dopamine and estrogen.
  • These impact mental rigidity, focus, and estrogen-related cancer risk.
INSIGHT

Interpreting StrateGene Report

  • The StrateGene report uses a color-coded system (red, yellow, green) to show COMT activity levels.
  • Yellow (+/-) indicates intermediate activity (50% of the population), not necessarily risk.
INSIGHT

Low COMT Activity

  • Low COMT activity (red, +/+) means less dopamine methylation, leading to mental rigidity and difficulty letting go of thoughts.
  • It also means lower estrogen methylation, potentially increasing estrogen-related cancer risk.
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