The Body of Evidence 164 - 2025 Year End Wrap Up - Part 1
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Dec 17, 2025 In a lively year-end gathering, the hosts tackle a variety of viewer questions. Christopher dives into the Epstein-Barr virus and its surprising links to multiple sclerosis and cancers. They discuss the challenges of developing an EBV vaccine and its potential to prevent serious diseases. Interesting debates arise over the future of heart disease vaccines and the perils of current anti-inflammatory treatments. The conversation also touches on the promise and challenges of stem cell therapies for heart repair, leaving listeners with a mix of hope and caution.
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Epstein‑Barr Virus Linked To Multiple Sclerosis
- Epstein-Barr virus (HHV4) is widespread and linked to cancers and likely to multiple sclerosis.
- A 2022 study of US military recruits found seroconversion to EBV increased MS risk by ~32-fold, suggesting causality.
EBV Is Near‑Universal But Falling In Rich Countries
- EBV infects most people: global adult seroprevalence is ~90–95%, but prevalence is falling in developed countries.
- Many infections are mild or asymptomatic, which complicates tracking and prevention.
Watch For An EBV Vaccine As Prevention
- Preventing EBV infection via a future vaccine could reduce EBV‑related diseases like lymphoma and possibly MS.
- Monitor vaccine trials to see if vaccination lowers long‑term autoimmune and cancer outcomes.