The Joe Cohen Show How Betaine and BHMT Influence Your Methylation | SNPit #19
Apr 30, 2024
Delving into the pivotal role of the BHMT gene in methylation, the podcast explores how betaine enhances the cycle and reduces homocysteine levels. Emphasizing a comprehensive evaluation of multiple genes, it highlights the significance of optimizing methylation for body and brain health.
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BHMT's Role in Methylation
- BHMT enzyme helps convert homocysteine into methionine using betaine as a methyl donor.
- This supports methylation crucial for DNA, proteins, lipids, and cell membrane integrity.
Methylation's Health Impact
- Proper methylation controls homocysteine, lowering cardiovascular risk.
- It also influences neurotransmitter synthesis and brain cell membrane fluidity essential for neurological health.
BHMT Gene Variant Effects
- BHMT SNP RS3733890 lowers conversion of betaine to dimethylglycine, impacting methylation.
- Reduced BHMT activity can decrease SAM-E levels, impairing methylation and neurotransmitter synthesis.