
Nikonomics - The Economics of Small Business 244 - The Math Behind a $100M Concierge Medicine Business with Sandeep Palakodeti
Oct 15, 2025
Dr. Sandeep Palakodeti, known as Dr. Deep, is the visionary founder of Velocity Health, where concierge precision medicine meets advanced diagnostics. In their engaging chat, he reveals why he departed esteemed institutions like the Mayo Clinic to tackle the challenges of the U.S. healthcare system. They discuss how Velocity's model contrasts sharply with traditional care, focusing on preventative approaches and personalized strategies. Dr. Palakodeti also highlights the power of metrics like VO2 max for longevity and the business mechanics behind a thriving cash-pay model.
AI Snips
Chapters
Books
Transcript
Episode notes
Reconstructing Sick Care Into Preventive Care
- Velocity Health reconstructs care to be proactive, preventive, and individualized rather than reactive sick-care.
- Sandeep Palakodeti built a team-based clinic focused on long-term optimization and root-cause medicine.
Family Cardiac Crises Shaped His Mission
- Sandeep rushed to hospitals for family cardiac events and lost grandparents to early heart attacks, shaping his preventive focus.
- Those personal experiences motivated him to redesign care to prevent similar outcomes.
Primary Care Is Too Transactional
- The average US primary care visit lasts about seven minutes and physicians interrupt patients within 30 seconds.
- That transactional model makes patients feel like numbers and prevents deep, individualized care.

