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Sam Altman's startup principles emphasize the importance of optimism, relentless effort, and critical thinking as key traits for starting a business. Altman challenges the notion that being an optimist can lead to blind spots, arguing that it actually encourages critical thinking and a realistic assessment of potential challenges. He also emphasizes the need for relentlessness, being willing to go to any lengths necessary to bring a business idea to life. Lastly, critical thinking is highlighted as crucial for adapting and making necessary changes based on customer feedback.