Trending With Impact: Retired Sled Dogs in Aging Research

Whether they are sprinters or distance runners, sled dogs are known for their competitive nature and athletic prowess. With age, however, these athletes eventually run out of steam—just as humans inevitably do. Canines of all breeds are effected by aging, including a loss of resilience, accumulation of molecular damage and age-related diseases. These relatively short-lived, large mammals are one of the few to share environments with humans, and even have access to advanced medical care. Many believe the canine aging process resembles human aging the closest compared to any other animal. A team of scientists—from Cornell University, North Carolina State University, Tauber Bioinformatic Research Center, and Roswell Park Comprehensive Cancer Center—saw the opportunities and advantages of studying canine aging in a controlled environment. Co-founders Andrei Gudkov, PhD, Dr Sci, Katerina Andrianova, PhD, and Daria Fleyshman, PhD, established a non-profit organization called Vaika Inc. In 2018, Vaika allowed these researchers to begin collaborating in a longitudinal study on the mechanisms of aging among 103 retired sled dogs. The researchers authored a trending research perspective about the details of their long-term study. In September 2021, their paper was published on the cover of Aging (Aging-US)’s Volume 13, Issue 18, and entitled, “Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs.” Full blog - https://www.impactjournals.com/journals/blog/aging/trending-with-impact-retired-sled-dogs-in-aging-research/ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203600 DOI - https://doi.org/10.18632/aging.203600 Full text - https://www.aging-us.com/article/203600/text Correspondence to: Andrei V. Gudkov email: andrei.gudkov@roswellpark.org and Ekaterina L. Andrianova email: kandrianova@vaika.org Keywords: canine, senescence, frailty, longevity, healthspan About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ or connect with us on: Twitter - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ SoundCloud - https://soundcloud.com/aging-us​ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging​ Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM