The Gillett Health Podcast This one thing is clogging arteries
Oct 27, 2025
Discover the intriguing new data on lean mass hyper-responders and its implications for heart health. Dive into the differences between total plaque scores and the CLEARLY method, revealing why accurate analysis matters. Learn about the clinical significance of plaque progression rates and how dietary adjustments can modify risk factors. The hosts discuss the effects of imaging on participants' long-term care decisions and tackle radiation concerns with monitoring techniques. Lastly, get a sneak peek at future analyses in plaque progression.
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Different Tools, Different Plaque Results
- Different plaque analysis methods can produce different results on the same scans.
- HeartFlow and Clearly produced similar trends but differed in how many regressors versus progressors they found.
Total Plaque Score Can Hide Changes
- Total plaque score can obscure meaningful changes across coronary segments.
- Kyle warns that dividing vessels into segments and summing stenosis can hide real plaque progression.
HeartFlow Infers Plaque From Flow
- HeartFlow infers plaque from blood flow rather than directly measuring plaque.
- That makes HeartFlow more of a functional test focused on flow (FFR) than a direct plaque quantifier.