Prevent Alzheimer's and Optimize Your Brain for Longevity with Dr David Perlmutter

Jun 10, 2025

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In this episode, Dr. David Jockers and Dr. David Perlmutter explore the root causes of Alzheimer’s and cognitive decline, focusing on metabolic dysfunction rather than amyloid plaques. Dr. Perlmutter explains how insulin resistance and metabolic disturbances contribute to neurodegeneration.

They dive into the role of elevated uric acid in brain health and its connection to dementia and Alzheimer’s risk. Dr. Perlmutter shares actionable steps to manage uric acid levels and improve cognitive function through diet and lifestyle changes.

Learn how to support brain health by balancing blood sugar, nourishing gut bacteria, and incorporating healthy fats. Dr. Perlmutter offers insights on the foods and habits that protect your brain from decline.

In This Episode:

00:00 Understanding Uric Acid and Its Impact
03:12 Interview with Dr. David Perlmutter
05:00 The Rise of Alzheimer's Disease
06:08 Challenges in Alzheimer's Treatment
07:36 Metabolic Factors in Alzheimer's
11:44 Lifestyle Choices to Prevent Alzheimer's
16:42 Key Lab Markers for Cognitive Health
24:55 The Role of Uric Acid in Metabolic Diseases
32:10 Understanding Digestive Issues: The Role of Stomach Acid
34:04 Uric Acid and Its Impact on Health
34:59 Fructose, Diet, and Metabolic Health
41:31 The Role of Nitric Oxide in Health
44:53 Dietary Recommendations for Cognitive Health
54:47 Daily Routine and Lifestyle Tips
58:32 Final Thoughts and Empowerment

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"Alzheimer’s is not a disease of beta amyloid; it’s about brain metabolism and glucose utilization."

~ Dr. Jockers

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Resources:

Get 15% off Paleovalley Beef Tallow: paleovalley.com/jockers – Use code JOCKERS
Save 20% on Just Thrive Digestive Bitters: justthrivehealth.com – Use code JOCKERS

Connect with Dr. David Perlmutter:

Website: https://drperlmutter.com/

Connect with Dr. Jockers:

Instagram – https://www.instagram.com/drjockers/
Facebook – https://www.facebook.com/DrDavidJockers
YouTube – https://www.youtube.com/user/djockers
Website – https://drjockers.com/

If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/