The Curious Clinicians
77 - Irregularly Irregular
Sep 21, 2023
The podcast explores the relationship between hyperthyroidism and atrial fibrillation, including the effects of hyperthyroidism on the heart and the potential causes of AFib. It also discusses the impact of T3 on cardiomyocytes, the association between fibrosis and hyperthyroidism, and the effects of thyroid-stimulating hormone levels on AFib risk.
28:20
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Quick takeaways
- Hyperthyroidism can cause atrial fibrillation through acute sympathetic activation and long-term fibrosis.
- Hypothyroidism does not protect against atrial fibrillation and guidelines lack specific recommendations for subclinical cases.
Deep dives
Hyperthyroidism and AFib: The Acute and Long-term Effects
Hyperthyroidism can cause atrial fibrillation (AFib) through both acute and long-term mechanisms. In the acute phase, hyperthyroidism leads to sympathetic activation and increased heart rate, creating an environment for AFib to develop. The increased heart rate and decreased atrial refractory period contribute to the initiation and maintenance of AFib. Additionally, hyperthyroidism can induce fibrosis in the longer term, increasing the likelihood of AFib. While the risk of AFib is higher in severe hyperthyroidism, even subclinical hyperthyroidism poses a heightened risk.
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