What cofactors are needed to synthesize and recycle BH4? | Masterjohn Q&A Files #319

Jul 17, 2023

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Question: What cofactors are needed to synthesize and recycle BH4? Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR). This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:

https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-sulfate-synthesis

In that batch of free episodes you will also find the answers to these questions:

Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
How Much Iron Can We Absorb At Once?

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https://chrismasterjohnphd.substack.com/qanda

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https://chrismasterjohnphd.substack.com/about

This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
How Much Iron Can We Absorb At Once?
What nutrients are important for long-term PPI use?
For how long does transferrin saturation respond to recent iron-rich food?
Muscle spasms: creatine, creatinine, sodium, and potassium.
Hematologists ignore iron saturation.
How to detox arsenic?
Could folic acid supplements impair BH4 recycling?
How to increase butyrate?
More on hematologists and transferrin saturation.

Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-february

Access the show notes, transcript, and comments here.