NYU Langone Insights on Psychiatry Frontiers of Psychopharmacology (with Charles Nemeroff, MD, PhD)
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Mar 5, 2024 Dr. Charles Nemeroff discusses childhood maltreatment as a risk factor, advances in precision psychiatry, and the potential of psychedelics in disrupting mental health disorders. The podcast also explores the use of psilocybin for anorexia nervosa, transcranial magnetic stimulation, and the challenges of prescribing MAOIs.
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Childhood Maltreatment's Impact
- Early life stress, like maternal separation, causes lasting brain and body changes in lab animals.
- Similar effects are seen in humans, with childhood maltreatment increasing vulnerability to depression, bipolar disorder, and PTSD.
Precision Psychiatry's Potential
- Current commercial genetic tests for predicting antidepressant response lack validity.
- Personalized medicine's future is bright, with polygenic risk scores improving risk prediction for disorders like schizophrenia, PTSD, and depression.
Psychedelic Medicine's Efficacy
- MDMA shows robust effects in treating severe, treatment-resistant PTSD in randomized controlled trials, although blinding is an issue.
- Psilocybin demonstrates efficacy in treatment-resistant depression, but the effect size is less pronounced than MDMA for PTSD.