NYU Langone Insights on Psychiatry

What if mental health care worked more like cancer treatment—tailored to the individual, informed by biology, and driven by data? Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, takes us through the latest advances in precision psychiatry. From brain imaging to digital phenotyping, Dr. Marmar outlines the tools shaping a future where treatment is fully customized. He also shares stories from the front lines: a patient whose depression was treated with the help of a brain biopsy, why PTSD and depression aren’t one-size-fits-all, and how quantum computing could radically accelerate psychiatric research.🔍 Topics Covered00:00 Introduction02:24 Personalized Treatment Approaches05:13 Challenges in Precision Psychiatry11:12 The Role of Genomics and Brain Imaging23:35 Digital Psychiatry and AI25:57 Quantum Computing in Psychiatry33:04 Future of Precision Psychiatry37:22 Conclusion📚 Related ResourcesCharles Marmar, MD – NYU Faculty ProfileNYU Langone Psychiatry Adriana Heguy, PhD – NYU Faculty Profile Javad Shabani, PhD – NYU Faculty Profile🙌 Support & SubscribeIf this episode challenged your thinking, like, share, and subscribe to help bring smart, science-forward conversations to a wider audience.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

There’s a care model for schizophrenia that actually works—why isn’t it everywhere? On this episode, W. Gordon Frankle, MD, MBA, Vice Chair of Psychiatry at NYU Langone Health, shares how his team in Brooklyn is building a new model for treating serious mental illness—one rooted in long-term, relationship-driven, team-based care. From wraparound services to precision psychiatry, this conversation explores what happens when you bring humanity, structure, and innovation to a population too often left behind.Also discussed:The first novel schizophrenia drug in over 50 years (Cobenfy)Why clozapine is underused—and how that may finally changeThe potential of brain imaging and biomarkers in psychiatric treatmentWhat a real community mental health system looks likeWhy trust, not just treatment, is essential for recovery🔍 Topics Covered00:00 Introduction00:30 Dr. Frankle's Current Work01:08 Advancements in Schizophrenia Research02:29 Challenges and New Treatments in Schizophrenia05:02 Precision Medicine in Psychiatry05:59 PET Scans and Brain Energetics09:46 Barriers to Effective Treatment11:51 Clozapine and Treatment Access13:38 Wraparound Services and Community Care14:46 Early Screening and Public Health Interventions18:32 Mandated Treatment and Patient Engagement30:08 Homelessness and Mental Health34:54 Future Directions in Schizophrenia Treatment38:09 Conclusion📚 Related ResourcesW. Gordon Frankle, MD, MBA Schizophrenia care at NYU Langone NYU Langone Hospital—Brooklyn 3 Things to Know About Cobenfy (Yale Medicine) 🙌 Support & EngageIf you enjoyed this episode, please like, share, and subscribe to support real conversations about transforming mental health care.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs. Dr. Siegel is an assistant professor at NYU Grossman School of Medicine.🔍 Topics Covered:00:00 Introduction00:15 Dr. Siegel's Current Work01:01 Past Research and Human Psilocybin Imaging Study02:39 Understanding Brain Changes and Biomarkers06:13 Mechanisms of Action and Plasticity12:51 Surprising Findings and Context Dependence16:34 Challenges and Future Directions in Psychedelic Research20:46 Advanced Imaging and Personalized Treatment Plans24:15 Setbacks and Lessons in Psychedelic Medicine28:40 Emerging Areas in Neuropsychopharmacology31:46 Conclusion📚 Related Resources:Joshua Siegel, MD, PhD  NYU Langone Health’s Center for Psychedelic MedicineThe Multidisciplinary Association for Psychedelic Studies (MAPS)“Psychedelic and Dissociative Drugs as Medicines” (NIH) 🙌 Support & Engage: Enjoyed this episode? Like, comment, and share to support science-based conversations about mental health.🔔 Don’t forget to subscribe for more interviews with top psychiatric researchers.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

What if a simple conversation in the emergency room could reveal who’s most at risk for PTSD before symptoms even begin? Katharina Schultebraucks, PhD, shares her innovative work on using machine learning to forecast mental health outcomes and explains how AI could revolutionize how we detect, prevent, and treat psychiatric disorders. Dr. Schultebraucks is Co-Director of the Computational Psychiatry Program and Associate Professor in the Department of Psychiatry and Population Health at NYU Grossman School of Medicine.🔍 Topics Covered00:00 Introduction00:23 Current Work and Research Focus01:29 Objective Measures in Psychiatry02:50 Predicting PTSD Risk04:28 Early Preventive Interventions05:47 Machine Learning in Mental Health09:49 Challenges and Surprises in Research22:46 Burnout in Emergency Department Providers27:17 Precision Psychiatry and Future Directions29:35 Conclusion📚 Related Resources-Katharina Schultebraucks, PhD -Computational Psychiatry Program in NYU Langone’s Department of Psychiatry -“Dissecting racial bias in an algorithm used to manage the health of populations” by Ziad Obermeyer, et al -PTSD Treatment at NYU Langone Health 🔔 Subscribe for more conversations at the intersection of mental health and innovation.📢 Like, comment, and share if this episode sparked your thinking.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

How do you help a child with ADHD stay organized, on task, and confident in school? Richard Gallagher, PhD, a child and adolescent psychologist at NYU Langone Health, shares groundbreaking research on organizational skills training for children with ADHD—a behavioral treatment that’s changing lives and improving classroom performance. This episode dives into how executive functioning challenges manifest in real life, the strengths (and limits) of technology, and the power of parent training and therapeutic coaching to help children thrive.Dr. Richard Gallagher is Associate Professor in the Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine, and Director of the Organization Skills Program.🔍 Topics Covered00:00 Introduction00:19 Current Research on Organizational Skills01:06 Executive Functioning and Practical Interventions02:37 Impact of Interventions on ADHD04:41 Expanding Research and Brain Connectivity05:08 Medication and Organizational Skills08:11 Technology in ADHD Assessment15:39 Effective Parenting Styles for ADHD23:10 Non-Pharmacological Treatments and Future Research25:58 Conclusion and Final Thoughts📚 Related Resources👨‍⚕️More about Dr. Richard Gallagher 🔬 NYU Child Study Center 📘 “Organizational Skills Training for Children with ADHD” by Richard Gallagher, Howard B. Abikoff, and Elana G. Spira  📝 CHADD Parent Training Resources📈 CDC ADHD Parent Guide🙌 Support & EngageIf this episode was helpful, please like, share, and subscribe to support the series and spread awareness about evidence-based ADHD care.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

ADHD isn’t just a childhood condition—many adults go undiagnosed for years. Lenard Adler, MD, Director of the Adult ADHD Program at NYU Langone Health, breaks down the nuances of ADHD in adults, the challenges of proper diagnosis, and the latest treatments available. Learn about his research, the screening tools his team has developed, and what’s on the horizon for adult ADHD care.🔍 Topics Covered:00:00 Introduction00:44 Dr. Adler’s Current Research Focus01:47 Importance of Proper Assessment03:44 Challenges in Diagnosing Adult ADHD06:15 Gender Differences in ADHD Diagnosis07:51 Impact of ADHD on Lifespan10:10 Comorbidities and Treatment Approaches14:54 Medication and Treatment Strategies21:15 Medication Shortages and Solutions28:42 Recent Developments in ADHD Research35:01 Screening and Diagnostic Tools37:33 Conclusion📚 Related Resources:Lenard A. Adler, MD (official bio)Adult ADHD Program at NYU Langone HealthAdult Self-Report Scale (ASRS) ScreenerLife expectancy and years of life lost for adults with diagnosed ADHD in the UK: matched cohort study | The British Journal of PsychiatryAmerican Professional Society of ADHD and Related Disorders (APSARD)CHADD: ADHD Resources and Support🙌 Support & Engage: If you found this episode helpful, please like, comment, and share to spread awareness.🔔 Don’t forget to subscribe to stay updated on new episodes.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

Despite affecting more Americans than diabetes, substance use is often left out of routine medical care. In this episode, NYU Langone Health’s Jennifer McNeely, MD—a clinician investigator, primary care and addiction medicine physician—explains why that must change. From the surprising history behind addiction’s exclusion from mainstream medicine to the innovative screening tools shaping the future of care, this conversation is a must-listen for anyone interested in addiction care and healthcare policy.Jennifer McNeely, MD, is an Associate Professor of Medicine and Population Health at NYU Grossman School of Medicine and co-director of the Section on Tobacco, Alcohol, and Drug Use.🔍 Topics Covered:00:00 – Introduction01:15 – Why addiction hasn’t been part of traditional medical care05:00 – What medications can primary care providers actually prescribe?07:00 – Why lifting legal barriers isn’t enough08:00 – Making substance use screening part of routine care11:50 – The power of self-report screening tools13:30 – What primary care physicians can actually do after screening16:10 – Real-world clinical impact of identifying substance use18:00 – Overcoming stigma and “we don’t do that here” culture22:17 – Can AI help with screening and care prioritization?📚 Related Resources:Jennifer McNeely, MDAddiction Treatment at NYU LangoneNIDA’s Resources for CliniciansSubstance Use Screening Tools (NIDA)🙌 Support & Engage: If you found this episode helpful, please like, comment, and share to spread awareness.🔔 Don’t forget to subscribe to stay updated on new episodes.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

What makes addiction treatment truly effective? Behavioral scientist Charles Neighbors, MBA, PhD, shares groundbreaking research on the importance of therapeutic relationships, harm reduction, and human connection—love!—in treating substance use disorders. Dr. Neighbors is an Associate Professor in the Departments of Population Health, and Psychiatry at NYU Grossman School of Medicine.💡 Topics Covered00:00 Introduction to Dr. Charles Neighbors01:37 The biggest challenges in addiction treatment02:24 The Importance of Therapeutic Relationships05:59 Defining “good treatment” and why love matters08:05 The role of therapeutic alliance in patient outcomes14:06 Barriers to change in addiction treatment systems (incl. stigma)22:04 Harm reduction and safe injection sites: What does the science say?30:36 Future directions in addiction policy and treatment📚 Related ResourcesCharles J. Neighbors, MBA, PhD (official bio)Dr. Neighbors’ Lab - Health Evaluation & Analytics Lab (HEAL)Addiction Treatment at NYU LangoneUnderstanding Harm Reduction: National Institute on Drug Abuse (NIDA)"Motivational Interviewing" by William R. Miller and Stephen RollnickCommunity Reinforcement and Family Training (CRAFT)SAMHSA’s National Helpline for Mental Health, Drug, Alcohol IssuesNew York State Office of Addiction Services and Supports (OASAS)🔔 Subscribe for more insights on mental health & addiction treatment!👍 If you found this video helpful, please like, comment, and share to spread awareness!Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

For the final episode of Season 2, we're joined by Dr. Samuele Cortese, Professor of Child and Adolescent Psychiatry at the University of Southampton (UK) and Adjunct Full Professor at NYU Langone. Together we explore the intersection of pediatric ADHD and precision psychiatry, including the disorder’s genetic underpinnings and evolving treatment options.00:00 Introduction00:54 Dr. Cortese's Research Journey02:11 Global Perspectives and Challenges in ADHD Treatment03:51 Advances in ADHD Diagnosis and Treatment06:41 Role of Genetics in ADHD09:33 Precision Treatment and Stratification12:17 Treatment Adherence and Shared Decision-Making23:55 Connection Between ADHD and Obesity28:39 Non-Stimulant Alternatives and Future Directions in ADHD Treatment32:16 Non-Pharmacological Treatments37:28 Advice for Clinicians and Closing ThoughtsVisit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

Dr. Timothy Wilens is a Professor of Psychiatry at Harvard Medical School and Chief of the Division of Child and Adolescent Psychiatry at Massachusetts General Hospital. His research interest include the relationship between ADHD, bipolar disorder, and substance use disorders; ADHD pharmacotherapy; and stimulant medication misuse.On this episode, Dr. Wilens discusses the importance of early diagnosis and intervention in ADHD, as well as its lifelong implications. He takes us through the evolution of ADHD treatment, from behavioral therapies to modern pharmacological interventions, including stimulant and non-stimulant medications, and the application of digital therapeutics. The conversation also touches on the stigma surrounding ADHD, the role of precision medicine, and the future of ADHD research.00:00 Introduction02:50 Evolution of ADHD Treatment04:43 Stigma and Misconceptions12:18 Importance of Early Intervention15:02 ADHD Symptoms and Treatment Approaches30:02 Addressing Concerns About Stimulant Medications35:50 Navigating the Complexities of ADHD Medication41:22 Future of ADHD Research and Treatment43:20 ConclusionVisit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle