Join Jason and Brenda at IMMUNOLOGY2024 as they discuss sessions on innate and innate-like cells and transplant immunology. Topics include hypothermia for lung damage protection, Siglec-E knockout in transplant rejection, jet lag strategies, NK cell development, inflammation, and risks in transplantation immunology.
Hyperthermia protects against ventilator-induced lung injury by eliminating gasdermin D activation and net formation.
LAC-3 regulates antibody responses in kidney transplantation, correlating with reduced rejection and antibody-mediated responses.
Deep dives
Hyperthermia's Role in Protecting Against Ventilator-Induced Lung Injury
Hyperthermia has been shown to protect against ventilator-induced lung injury by eliminating gasdermin D activation and net formation. Studies revealed that depleting neutrophils with an antibody can limit injury without affecting IL-1 beta release, highlighting the detrimental role of neutrophils in lung injury and the potential for therapies targeting this pathway.
Regulating Antibody Responses Following Kidney Transplantation
LAC-3 has been found to regulate antibody responses following kidney transplantation, particularly affecting both T and B cells. Research demonstrated that LAC-3 expression correlates with tolerance induction, showing reduced rejection and antibody-mediated responses in its presence. The study underscores the importance of LAC-3 in modulating immune responses in the context of kidney transplantation.
Enhancing Graft Protection Through Cell Modification
The introduction of truncated EGFR sequences into human pluripotent stem cells enabled the creation of CAR Tregs that could protect grafts. By directing CAR Tregs against stem cells expressing truncated EGFR, researchers demonstrated functional and regulatory qualities of these cells in protecting grafts in vitro and in vivo. This innovative approach opens new possibilities for protecting transplanted cells and improving engraftment outcomes.
In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting, in which Jason and Brenda highlight sessions on innate and innate-like cells and transplant immunology. Discussions include the role of hypothermia in protecting ventilator-induced lung damage and Siglec-E knockout in transplant rejection.
, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting, in which Jason and Brenda highlight sessions on innate and innate-like cells and transplant immunology. Discussions include the role of hypothermia in protecting ventilator-induced lung damage and Siglec-E knockout in transplant rejection.
