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Prolonged stress and elevated levels of cortisol and adrenaline can have harmful effects on the body. It can lead to shrinkage of the gray matter, atrophy of muscles, decreased testosterone levels, digestive issues such as acid reflux and constipation, and disrupted sleep. Humans have not evolved to handle sustained mental stress, which can cause a range of health problems, including ulcers, inflammation, and reactivation of dormant viruses.