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Key Initial Diagnostic Questions
- Always ask if thrombocytopenia is isolated, real, and new or chronic first.
- These questions guide the differential diagnosis and management approach.
Identify Emergencies First
- Prioritize determining if thrombocytopenia is an emergency before differential diagnosis.
- Emergencies include severe thrombocytopenia or conditions like HIT, TTP, DIC, and HUS.
Thrombocytopenia Framework
- Thrombocytopenia mechanisms fit into three buckets: decreased production, increased destruction, or increased sequestration.
- Most cases are multifactorial and hard to attribute to a single cause.