The Optispan Podcast with Matt Kaeberlein

Rapamycin: The Worst Longevity Idea Ever Conceived? | 110

Apr 22, 2025
Explore the fascinating debate on rapamycin as a longevity treatment. Discover how misinformation surrounding its side effects, like cataracts and glucose issues, is debunked with scientific evidence. Uncover the benefits often overlooked in studies, and learn about its potential applications in treating periodontal disease. The discussion dives deep into the biological mechanisms behind mTOR and fasting, while also emphasizing the need for more robust clinical trials. Prepare for a lively examination of truth versus myth in the world of longevity science!
Ask episode
AI Snips
Chapters
Transcript
Episode notes
INSIGHT

Rapamycin Benefits Outweigh Side Effects

  • Rapamycin extends lifespan in mice while showing overall healthspan improvements.
  • Some reported side effects like cataracts or glucose metabolism issues are either unreproducible or context-dependent.
INSIGHT

Rapamycin vs Fasting on Longevity

  • Claims that rapamycin only mimics fasting via mTOR inhibition are misleading.
  • Rapamycin increases lifespan much more effectively than fasting alone in mice.
INSIGHT

Rapamycin's Organ Effects Debunked

  • Rapamycin improves heart and liver function during aging in mice.
  • Negative claims about heart scarring and fattened liver lack evidence at longevity doses.
Get the Snipd Podcast app to discover more snips from this episode
Get the app