Sam Miller Science

S 765: Fasting Fundamentals Part 1: Understanding the Science, Physiology, and Popular Fasting Methods

Feb 22, 2025
Fasting is a hot topic, often misunderstood, and this discussion breaks it down. Various fasting methods and their biological mechanisms are explored, focusing on hormonal responses and energy dynamics. Listeners gain insights into who should or shouldn't fast, and the nuances of fasting for fat loss. The importance of raising awareness about metabolic health is emphasized, along with resources for further engagement. This engaging conversation sets the stage for more detailed fasting applications.
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INSIGHT

Calorie Deficit Drives Fat Loss

  • Fat loss necessitates a cumulative caloric deficit over weeks or months, regardless of fasting method.
  • Calories and macronutrients remain foundational, with fasting mainly affecting eating windows rather than overriding energy balance.
ADVICE

Use Fasting for Adherence

  • Use fasting as an adherence tool only if it naturally reduces caloric intake without causing overeating.
  • Avoid fasting if skipping meals leads to compensatory overeating that negates calorie deficit.
INSIGHT

Hormonal Dynamics in Fasting

  • The fasted state involves hormones like glucagon, cortisol, and catecholamines, while fed state features insulin.
  • The duration of fasted vs. fed hormonal dominance depends on total caloric intake and meal patterns.
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