The Joe Rogan Experience #2421 - Derek, More Plates More Dates
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Dec 2, 2025 
Derek, the fitness educator behind More Plates More Dates, dives deep into the world of supplements and performance. He outlines his new nootropic drink, explaining ingredients like alpha-GPC and caffeine for cognitive enhancement. Derek shares cautionary tales about past supplement dangers and discusses hormone replacement therapy myths. They also explore the risks actors face with extreme weight changes and how athletes use performance aids. Additionally, they touch on emerging therapies and the challenges of leg-lengthening procedures.
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Start Nootropics With Sustainable Doses
- Start with sustainable doses when stacking nootropics and stimulants to avoid tolerance and adverse effects.
- Use moderate caffeine (200 mg) and balanced cholinergics for daily cognitive benefit without overstimulation.
Saffron Shows Promising Mood Benefits
- Saffron shows antidepressant and anxiolytic effects in literature with fewer sexual and anhedonia side effects than SSRIs.
- It may operate through antioxidant and mixed monoaminergic pathways, offering benign mood support.
Pair Choline Fuel With Breaker Of Its Breakdown
- Combining cholinergic precursors with an acetylcholinesterase inhibitor can deliver a 'one-two punch' to raise available acetylcholine.
- This pairing may boost cognitive capacity more than either approach alone when dosed carefully.