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Brain's Immune System
- The brain was previously thought to be immune-privileged, with no lymphatic drainage.
- Recent discoveries of meningeal lymphatic vessels (MLVs) challenge this dogma, revealing complex brain-immune interactions.
Viral Entry and Exit
- Many viruses enter the brain via blood-brain barrier breaches, olfactory/trigeminal nerves, or CSF.
- This study explores if meningeal lymphatic vessels (MLVs) mediate viral exit.
Mice Brain Resilience
- Vincent Racaniello injected poliovirus directly into mice brains for research.
- Surprisingly, mice recovered quickly, highlighting their resilience.