Pondering Hormesis for Brain Performance and Resilience with Rehana Leak

Rehana Leak who is an Associate Professor of Pharmacology at Duquesne University and I discuss how cells respond adaptively to various types of mild stress by processes that fall under the umbrella of “hormesis”. During evolution organisms acquired many different ways of coping with and even using to their advantage of potentially damaging environmental factors such as exposures to metals, toxic gases, extreme temperatures, food scarcity, etc. Research findings  show that various means of engaging  adaptive stress response signaling pathways can be deployed to enhance brain performance and protect neurons against various neurological disorders.

 

Book: Hormesis: A Revolution in Biology, Toxicology, and Medicine:

https://www.amazon.com/Hormesis-Revolution-Biology-Toxicology-Medicine/dp/1627038515

 

Lecture on hormesis:

https://www.youtube.com/watch?v=ZpcVku45hFY

 

Review articles on hormesis:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096685/pdf/10.1177_1559325818784501.pdf

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248601/pdf/nihms39393.pdf

 

Scientific American article: ‘What doesn’t kill you…’:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841445/pdf/nihms946635.pdf