The Genetics Podcast EP 184: Rethinking speed and scale in clinical genomics with Euan Ashley of Stanford University
Apr 24, 2025
Euan Ashley, Chair of the Department of Medicine at Stanford and co-founder of biotech firms, shares insights from his groundbreaking work in ultra-rapid genome sequencing. He highlights a pivotal case of diagnosing a newborn's cardiac condition in just eight hours. Euan discusses the integration of AI and wearables in preventive medicine, as well as the genetics behind elite athletic performance. Additionally, he explores the ethical considerations of widespread genetic testing and the potential of generative AI in developing novel therapies.
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Ultra-Rapid Genomic Diagnosis Saves Infant
- A newborn in cardiac arrest was rapidly diagnosed with a potassium channel long QT syndrome using ultra-rapid genome sequencing.
- This diagnosis enabled precise treatment and saved the infant's life, demonstrating the power of rapid clinical genomics.
Faster Genome Sequencing with Nanopore
- Using Nanopore sequencing with optimized cloud-based computing reduced genome analysis time from 18 hours to under 8 hours.
- This innovation enables genome sequencing results within one nursing shift, transforming critical care diagnostics.
Scaling Rapid Genomics in NICUs
- To scale rapid genome sequencing to all neonatal ICUs requires establishing sustainable business models beyond academic labs.
- Overcoming reimbursement and regulatory challenges is essential for widespread clinical implementation.
