Inside Aesthetics Ep 333 The Tox Talks (Chapter 11): Relfydess | Mike Clague
Jan 15, 2026
Mike Clague, a seasoned nurse injector with over 20 years of experience, shares his insights on Relfydess, a new botulinum toxin. He discusses the unique benefits of Relfydess's liquid formulation and its rapid onset compared to other toxins. Mike dives into innovative injection techniques, like the 'upside-down T,' and practical tips for achieving optimal results. He also touches on the commercial implications of treatment frequency and stresses the importance of patient education and regulatory compliance in aesthetic practices.
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Liquid Strain And Purity Matter
- Relfydess is a new liquid Botulinum toxin with a distinct strain and manufacturing process that stays liquid rather than freeze-dried.
- Mike reports it feels purer and may offer slightly greater efficacy for patients who previously had short-lived responses.
Titrate First, Assume Never
- Start new-to-you toxins cautiously and titrate dose by area and patient history rather than assuming unit equivalence.
- For frontalis with Relfydess, Mike suggests higher doses (around 40–50 units) compared with other toxins and careful site placement.
Use An Inverted-T Forehead Pattern
- Use anatomical injection patterns (eg. an inverted T for frontalis) and avoid repeated injections along the same superior line.
- Place single targeted injections lateral above the eyebrow to elevate without causing brow descent.