The Contemplative Science Podcast
Rewiring Hope: Computational Models, Psilocybin, and the Science of Optimism w/ Beth Fisher
Dec 15, 2024
In a fascinating discussion, Beth Fisher, a PhD student at M3CS, unpacks her innovative research on psilocybin's effects on optimism and decision-making. She reveals how psilocybin can modify the brain’s approach to loss aversion and enhance hopeful engagement in rats. Delving into therapeutic potential, Beth discusses the role of environment in psychedelic therapy and how computational models help measure optimism. With insights into gratitude’s impact on perspective, she offers a unique lens on fostering resilience in challenging times.
35:20
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Quick takeaways
- Psilocybin enhances optimistic engagement and decision-making in rats, which may hold therapeutic implications for treating depression in humans.
- The study highlights the adaptive nature of optimism and its potential benefits, emphasizing the importance of individualized interventions for effective treatment.
Deep dives
The Impact of Psilocybin on Behavior
Research using a rat model has shown that psilocybin can influence behavior post-administration. In the study, rats treated with a clinical dose of psilocybin demonstrated more willingness to engage in tasks that could yield rewards compared to a control group. This behavior is analogous to human actions where individuals facing depression may also withdraw from engaging activities. The findings suggest that psilocybin may enhance engagement and decision-making, mirroring optimistic behavior seen in humans.
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