JAMA Clinical Reviews Treatment of Keratinocyte Carcinoma
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Oct 30, 2025 Mackenzie R. Wehner, an Assistant Professor of Dermatology at MD Anderson Cancer Center, dives into the world of keratinocyte carcinomas, a prevalent form of skin cancer. She discusses risk factors like UV exposure and the impact of childhood sunburns. Indoor tanning's contribution to cancer risk reveals alarming truths, while sunscreen advice highlights the importance of SPF 30+. Wehner clarifies how to distinguish actinic keratoses from more serious conditions, and emphasizes the need for regular skin exams and careful monitoring to minimize recurrence.
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Common Locations Differ By Type
- Keratinocyte carcinomas most often occur on the head and neck, making them visible but cosmetically concerning.
- Basal cell carcinoma favors the trunk while squamous cell carcinoma more commonly affects the arms.
UV Exposure Dominates Risk Profile
- UV radiation is the primary cause and lighter pigmentation, sunburn tendency, and indoor tanning increase risk.
- Older age, male sex, and immunosuppression (eg, organ transplant) also raise risk substantially.
Sunburns, Especially in Childhood, Matter
- Sunburns measurably increase risk: frequent sunburns double BCC risk and severe sunburns substantially raise SCC risk.
- Childhood UV exposure likely matters more than adult exposures due to longer latency for carcinogenesis.