Shuying Sun: RNA Dysregulation in Neurodegenerative Disorders – From Mechanisms to New Therapies

Recent discoveries show that some neurodegenerative disorders occur because of abnormalities in the processing of RNA in the cell nucleus and/or its export from the nucleus. Johns Hopkins University Associate Professor Shuying Sun is at the forefront of research that is establishing the molecular mechanisms responsible for RNA dysregulation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Her research is contributing to a rapid acceleration of understanding of the causes of ALS and FTD and to the development of new pharmacological and gene therapy-based treatments for these disorders.

LINKS

Dr. Sun's laboratory webpage:

https://sunlab.jhmi.edu/

Review article

https://pmc.ncbi.nlm.nih.gov/articles/PMC11790913/pdf/44318_2024_Article_352.pdf

Original research articles

https://pmc.ncbi.nlm.nih.gov/articles/PMC5754368/pdf/41467_2017_Article_2495.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC6895427/pdf/nihms-1539444.pdf

https://www.biorxiv.org/content/10.1101/2025.09.30.679260v1

https://www.biorxiv.org/content/10.1101/2025.09.30.679260v1

https://www.biorxiv.org/content/10.1101/2025.06.13.659508v1