JAMA Clinical Reviews Lipoprotein(a): What Clinicians Should Know
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Jun 3, 2025 Join Dr. Samia Mora, a Harvard cardiologist and expert on lipoprotein(a), as she dives into its pivotal role in cardiovascular health. She outlines the genetic factors affecting lipoprotein(a) levels and discusses its risks compared to LDL cholesterol. The conversation emphasizes the need for precise measurement, the implications of high levels, and recent advances in treatment options, including promising new therapies. Dr. Mora also stresses the importance of population testing for better heart disease prevention.
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Unique Structure and Risk of Lipoprotein(a)
- Lipoprotein(a) is an LDL-like particle but distinct because it carries apolipoprotein(a) made of Kringle type 4, 2 repeats.
- Its components promote atherosclerosis, thrombosis, and inflammation, contributing to cardiovascular risk.
Lp(a) Is Different from LDL
- Lipoprotein(a) is a different particle from LDL cholesterol, even though they share similarities.
- Measuring LDL cholesterol may include some Lp(a) cholesterol, but Lp(a) levels require specific measurement.
Interpreting High Lipoprotein(a) Levels
- Consider an Lp(a) level above 50 mg/dL or 125 nmol/L as high risk for cardiovascular disease.
- Pay attention to assay units as milligrams per deciliter measure mass, and nanomoles per liter count particles.