Current Approaches to Treating Pediatric Bipolar Disorder
Nov 18, 2023
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Explore the challenges and updates in treating pediatric bipolar disorder, including the use of FDA-approved medications since 2005. Learn about different treatment approaches, the importance of close monitoring, and comprehensive lifestyle changes. Discover the advantages and limitations of using lithium and second-generation anti-psychotics. Explore the best-practice treatment algorithms, including FDA-approved medications and non-medication options like CBT, while balancing efficacy and side effects.
FDA-approved treatments for Pediatric Bipolar Disorder include erypiprazol, acetopene, olanzopene, quatiapene, and raspiridone as first-line treatments for manic or mixed episodes.
For depressive episodes, lorazidone is recommended as the first-line treatment with augmentation options like lomotrigine or an FDA-approved SSRI such as fluoxetine or acetalopram.
Deep dives
FDA-approved treatments for Pediatric Bipolar Disorder
The FDA-approved treatments for Pediatric Bipolar Disorder include drugs such as erypiprazol, acetopene, olanzopene, quatiapene, and raspiridone. These drugs are recommended as first-line treatments for manic or mixed episodes of Pediatric Bipolar Disorder.
Treatment for Depressive Episodes
For depressive episodes of Pediatric Bipolar Disorder, lorazidone is recommended as the first-line treatment. Augmentation options include lomotrigine or an FDA-approved SSRI such as fluoxetine or acetalopram. It is important to use SSRI's in combination with a mood stabilizing agent to prevent a switch to mania, and non-medication options like CBT should be explored.
Balancing Efficacy and Side Effects
Despite the effectiveness of certain drugs for Pediatric Bipolar Disorder, they are often underused due to concerns about side effects. Side effects can be mitigated through strategies like proactive diet and exercise planning, and by using additional medications such as topyramate. Clinicians should balance the efficacy of the drugs with the potential burden of side effects and educate patients and their families about potential risks and benefits.
Pediatric bipolar disorder treatment has evolved significantly since 2005, moving beyond lithium to several FDA-approved treatments. However, the challenges remain: How do we choose the first-line treatment? How can we mitigate and monitor side effects? In this episode, we discuss the latest practice treatment algorithms for pediatric bipolar disorder.
Faculty: David Rosenberg, M.D. Host: Richard Seeber, M.D.