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Mayo Clinic Talks

Obesity Pharmacotherapy Management

Aug 6, 2024
Kristina M. Thurber, Pharm D., R.PH., specializes in obesity pharmacotherapy management at Mayo Clinic. In this discussion, she highlights the alarming obesity epidemic in the U.S. and the role of GLP-1 agonists in weight loss and diabetes management. Kristina explains how these medications work, their potential impact on weight loss expectations, and economic challenges facing patients. She also advocates for a holistic approach to obesity management, combining medication with lifestyle changes and emphasizes the importance of communication in patient care.
21:18

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Quick takeaways

  • GLP-1 agonists effectively support weight loss by enhancing insulin production and suppressing appetite, but should complement lifestyle changes.
  • The high monthly cost of GLP-1 medications significantly limits accessibility for many patients, highlighting the importance of comprehensive weight management strategies.

Deep dives

Role of GLP-1 Agonists in Obesity Management

GLP-1 agonists have emerged as a significant option in managing obesity by supporting weight loss alongside traditional methods like diet and exercise. These medications function through various mechanisms, including stimulating insulin production in the pancreas and suppressing appetite through effects on the brain's appetite regulatory center. They also slow down gastrointestinal motility, which helps individuals feel fuller for longer periods. While these medications can assist in weight loss, they are not a standalone solution and should be part of a comprehensive weight management strategy that includes lifestyle changes.

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