On Start the Week Andrew Marr talks to Jane McGonigal, a designer of alternate reality games, about her latest innovation SuperBetter. Designed to aid her recovery from a brain injury and subsequent depression, the game reportedly gives people a sense of control over their own health. Harnessing the mind in the fight against chronic illnesses is the subject of Jo Marchant's book, Cure, which looks at the latest research into the science of mind over body. Rational thought and magic went hand in hand in the Renaissance period and the philosopher AC Grayling looks back at the life of John Dee - mathematician, alchemist and the Queen's conjurer. The actor Simon McBurney tests the limits of perception and human consciousness as he recreates what it feels like to be lost in the remote part of the Brazilian rainforest. Producer: Katy Hickman.