PsychRounds: The Psychiatry Podcast The Antipsychotics: Risperidone (Risperdal)
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Sep 11, 2024 Discover the evolution of risperidone, its significance in modern psychiatry, and how it's used across different age groups. Dive into its mechanism as a D2 blocker and the impact of its active metabolite. Learn about dosing strategies, potential adverse effects like hyperprolactinemia, and the advantages of combining it with aripiprazole. Explore recent advancements such as long-acting injectables, their benefits, and how they enhance treatment options. A fascinating analysis of a pivotal antipsychotic medication awaits!
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Risperidone's Mechanism and Classification
- Risperidone was developed to replicate clozapine's efficacy without its severe side effects.
- At higher doses, it behaves similarly to typical antipsychotics, challenging the typical vs atypical distinction.
Wide FDA Approvals and Use
- Risperidone is approved for a wide age range and multiple conditions, including schizophrenia and irritability in autism.
- It's favored across child, adult, and geriatric psychiatric populations.
Pharmacology and Metabolism
- Risperidone is a strong D2 and 5-HT2A antagonist with an active metabolite called paliperidone.
- Its half-life varies widely, influenced by metabolism rates, impacting dosing.