00:00 - Start
01:10 - Ray's new newsletter
05:05 - Le Chatelier's principle, Lamarckian fish, Barbara McClintock
09:18 - Gilbert Ling, ATP "the queen of cardinal adsorbents," phase transitions, coacervates, rigor mortis
13:51 - "The role of ATP is not limited to the contraction cycle. It dominates the physical state of muscle even in rest, keeping it soft and pliable... rigor mortis is but a lack of ATP..." Albert Szent-Györgyi
14:43 - Does the activation of the heat shock proteins (HSPs) precede cell division?
16:02 - Niacinamide and solubility, energy loss, DNA repair
19:09 - What about gelatin?
20:85 - Estrogen activates HSPs, redox balance, progesterone inhibits HSPs, water economy
23:15 - Should we activate the HSPs?
25:12 - Will the activation of the HSPs leave a scar?
27:06 - "Energy deprivation stabilizing proteins"
29:37 - Metallic taste in the mouth, lipid peroxidation
30:20 - "Estrogen, hyperventilation, lactate, etc., increase serotonin, and I think it’s serotonin that directly increases PTH, and then PTH increases NO." Ray Peat (2017)
33:30 - The living cell is more susceptible in the fatigued state
38:23 - HSP inhibitors: tetracycline, progesterone, methylene blue, etc.
38:58 - Is PTH a "newer" part of the system?
40:25 - Is RAAS more ancient than the HPA?
40:54 - Ray Peat's newsletter, Progest-E from Kenogen, Ray's history with progesterone
45:24 - Why can progesterone fill-in for the adrenals but pregnenolone cannot?
48:14 - Are pregnenolone and progesterone "true" hormones?
49:25 - If someone has a sensitive stomach -- how can they take progest-E?
50:14 - Ray's thoughts on using DHT and testosterone, gynecomastia, finasteride, governing principles of health
55:40 - Is DHT always "safer" than testosterone? Ray's thoughts on TRT
58:34 - What does Ray think of as a "max dose" of aspirin at one time?
01:00:04 - What happens to the agaratine in mushrooms? Does the mushroom water contain agaratine?
01:01:26 - How to distinguish between a fungal and bacterial infection?
01:07:40 - Does Ray prefer pure olive oil over coconut oil for the carrot salad and mushrooms? 1/2 a teaspoon provides a trace of PUFA
01:08:39 - Are fungal infections rarer than bacterial infections?
01:09:20 - H.pylori infection -- how to treat? Thoughts on dosing antibiotics
01:12:41 - The two-week time frame for antibiotic use scientific?
01:13:45 - Is antibiotic resistance important for the individual?
01:14:28 - Does antibiotic use cause a fungal overgrowth?
01:16:05 - Tetracyclines as antifungals? Inflammation predisposes to infection, feeling "uncomfortable" on minocycline
01:19:16 - Danny's experience on minocycline
01:21:46 - Question: why would a virus want to invade a cell?
01:29:28 - Viruses and weakened organisms
01:30:57 - Do viral pandemics exist?
01:36:02 - “...That is, if one pursues any ‘physical’ illness far enough and deep enough, one will find inevitably intrapsychic, intrapersonal, and social variables that are also involved as determinants.” Maslow (1993)
01:38:08 - What's the factor in the environment that's leading to frailty in young people?
01:40:42 - If a group has a problematic "death culture" holy book -- how can a functioning society be maintained?
01:44:54 - Could a holistic view of science be a foundation for a functional society?
01:45:51 - What is the long-term "artificial" struggle between humans?
01:47:10 - Does authoritarianism have anything to do with nature? +more