Long Covid Podcast 196 - Cellular Recharge: Can Nicotinamide Riboside help in Long Covid Recovery?
I'm joined today by Edmarie Guzman-Velez & Rudy Tanzi as we dig into a clinical trial of nicotinamide riboside for Long Covid, why NAD matters for cellular energy, and where the results show promise for fatigue, sleep, mood, and executive function. We share what worked, what did not, and the next steps.
• Overview of NAD, mitochondria, and energy in brain and immune cells
• Why Covid may deplete NAD and how NR restores it
• Trial design using intra-individual crossover with placebo run-in
• Dosing at 2,000 mg NR daily under IRB oversight
• Serial NAD blood measurements confirming a threefold rise
• Outcomes on fatigue, sleep quality, depressive symptoms, executive function
• Limits of small samples and reinfection attrition
• Safety, label guidance, and medical supervision for supplements
• Plans for biomarkers of inflammation and activity data from wearables
• Future research on symptom clusters, sex differences, and combinations
Links:
Full paper available HERE
Dr. Tanzi is paid consultant for, and equity holder in Niagen Biosciences.
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(music credit - Brock Hewitt, Rule of Life)
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**Disclaimer - you should not rely on any medical information contained in this Podcast and related materials in making medical, health-related or other decisions. Please consult a doctor or other health professional**