Bryan Johnson Podcast Psilocybin, LSD & Marijuana: Ranking Drugs for Longevity (Part 2)
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Sep 11, 2025 Dive into an intriguing exploration of psychedelics and their potential role in longevity! Discover fascinating studies linking psilocybin, LSD, and DMT to extended lifespans. The conversation also covers the complex effects of marijuana, including its relationship with sleep, anxiety, and aging. Personal experiences with these substances provide humorous insights, while important health risks of cannabis use are revealed. Tune in for a thoughtful discussion on the benefits and challenges of these mind-altering substances in pursuit of a longer life!
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Hosts’ Early Marijuana Experiences
- Kate and Mike both described first drug exposures to marijuana in adolescence via friends' households.
- Bryan described seeing a friend construct a makeshift smoking pipe at age 15 and declining to try it then.
Psilocybin Shows Early Longevity Signals In Mice
- Preliminary mouse data suggests monthly psilocybin extended lifespan and lengthened telomeres in older mice.
- The mechanism may involve 5-HT receptor activation and SIRT pathways but remains unproven in humans.
Use Legal Channels Or IRB For Psilocybin
- Legality varies: Oregon and Colorado permit medical psilocybin while other states do not.
- Travel to legal jurisdictions or conduct IRB-approved research if you plan supervised psilocybin use for study.