Docs Who Lift Cortisol Myths vs Reality: What Your Adrenals Actually Do
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Jan 7, 2026 
Dr. Richard Aukas, an endocrinologist specializing in adrenal health, discusses the vital role of cortisol in stress response and its circadian rhythm. He clarifies the complexities around diagnosing adrenal disorders and the challenges faced with cortisol testing. Richard dives into Cushing's syndrome and its signs, emphasizing the importance of early detection. He also shares insights from the CATALYST trial, revealing how glucocorticoid antagonism can impact diabetes management and hints at future therapies. Plus, a quirky anecdote connects hormone levels to woolly mammoths!
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Cortisol's Daily Rhythm Matters
- Cortisol is a circadian stress hormone that rises in the early morning and should be near zero at night.
Chronic Cortisol Causes Catabolism
- Chronic cortisol elevation produces a catabolic state that breaks down muscle, bone, and skin to fuel the brain.
Abnormal Cortisol Often Has Non-Adrenal Causes
- Cortisol levels vary widely and many abnormal results reflect non-adrenal causes like illness, medications, or sleep disorders.