JAMA Clinical Reviews Gastric Cancer Worldwide
Jan 7, 2026
Haeseong Park is an Associate Professor of Medicine at Dana-Farber Cancer Institute and an expert in gastrointestinal oncology. In this discussion, he highlights the alarming rise of gastric cancer incidence among younger individuals and its status as a leading cause of cancer deaths globally. Park delves into the significant role of Helicobacter pylori, along with other modifiable risk factors like smoking and obesity. He also contrasts screening methods between the U.S. and countries with national programs, emphasizing the need for improved prevention strategies and tailored treatment approaches.
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Shifting Incidence And Survival Trends
- Gastric cancer incidence is declining overall in the U.S. but rising in younger people.
- Survival has improved even as incidence shifts toward younger populations.
H. pylori Is A Preventable Driver
- Helicobacter pylori is a common, modifiable infectious risk factor linked to distal gastric cancers.
- Eradicating H. pylori reduces population gastric cancer incidence and may prevent individual cancers.
Modify Risk Factors To Lower Risk
- Reduce tobacco, excessive alcohol, obesity, and high salt intake to lower gastric cancer risk.
- Treat H. pylori infections early to prevent progression to cancer when detected.