The Dr Louise Newson Podcast 20 - Hormones and metabolism: Unlocking the science with Professor Franck Mauvais-Jarvis
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Aug 12, 2025 Dr. Louise Newson talks with Franck Mauvais-Jarvis, a Tulane University endocrinologist specializing in metabolism. They explore the essential role of oestradiol in metabolism, memory, and inflammation reduction. Professor Mauvais-Jarvis emphasizes how mitochondrial function impacts metabolic health, helping prevent diabetes. They also clarify misconceptions from the Women’s Health Initiative about hormone therapy, while highlighting testosterone's importance in women's health, especially post-menopause. Don't miss his insights on precision hormone therapy!
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Early Family Experiment Led To Transdermal Estrogen
- Franck Mauvais-Jarvis recounts his father testing skin absorption of radioactive estradiol on his mother in 1969.
- That early experiment showed steroid hormones could be absorbed through skin and led to later transdermal products.
WHI Misinterpretation Hid Nuanced Risks
- The 2002 WHI results were widely misinterpreted and led to blanket fear about all hormones.
- Subsequent analysis shows estradiol alone often reduces breast cancer risk while synthetic progestins raised concerns.
Estradiol Lowers Diabetes Risk Via Liver And Mitochondria
- Estradiol substantially reduces diabetes risk by improving insulin sensitivity and lowering visceral fat.
- Oral estradiol has stronger metabolic effects than transdermal due to first-pass liver metabolism.
