Adding Tirzepatide vs Prandial Insulin to Basal Insulin, Beta-Blockers in Septic Shock, USPSTF on Oral Health Screening, and more
Nov 7, 2023
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This podcast discusses topics such as the efficacy of Chrysepatide and Insulinless Pro in Type 2 diabetes, the use of Landial Lald in Septic Shock, alcohol use disorder therapies, AI in radiology, sepsis management, drug price negotiations, prevention research, oral health screening, non-alcoholic fatty liver disease management, health equity in AI tools, and climate change's impact on mental health in Africa.
Tirzepatide demonstrated better outcomes in Type 2 diabetes compared to Insulinless Pro.
Oral naltrexone and acamprosate showed promise in treating alcohol use disorder.
Deep dives
Chrysepatide vs. Insulinless Pro in Type 2 Diabetes
A Phase 3 clinical trial compared the efficacy and safety of Chrysepatide and Insulinless Pro as adjunctive therapies to basal insulin in Type 2 diabetes. Chrysepatide showed a statistically significant improvement in hemoglobin A1C levels, less hypoglycemia, and more reduction in body weight compared to Insulinless Pro.
Lidial Lald and Organ Failure in Septic Shock
A Phase 2B trial evaluated the use of Beta blockade with Lidial Lald to reduce organ failure in patients with Tachycardia and established Septic Shock. However, the trial was stopped due to possible harm in the Lidial Lald group, with no significant reduction in organ failure compared to standard care.
Pharmacotherapy for Alcohol Use Disorder
A meta-analysis of clinical trials examined the efficacy of nine therapies for alcohol use disorder in the U.S. Oral naltrexone and acamprosate were found to significantly improve alcohol consumption-related outcomes compared to placebo, suggesting their potential as first-line therapies along with psychosocial interventions.