Neurology® Podcast
Transcobalamin Receptor Antibodies in Autoimmune Vitamin B12 Central Deficiency
Jul 22, 2024
Dr. Michael R. Wilson and Dr. John Pluvinage discuss their discovery of anti-CD320 antibodies in B12 deficiency patients with neurological symptoms, highlighting potential implications for diagnosis and treatment. They explore the role of antibodies impairing B12 transport into the brain, new insights into autoimmune neurology, and advancements in understanding autoimmune diseases.
15:52
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Quick takeaways
- Autoantibodies targeting CD320 affect B12 transport into the brain.
- Immunotherapy and B12 supplementation can improve cognitive function in B12 deficiency patients.
Deep dives
The Journey of B12 Absorption
B12 absorption begins with ingestion of animal products, binding with intrinsic factor in the stomach, and transportation across the gut's blood barrier by the cubam receptor. Once in the blood, the active form of B12, holotranscobalamin, is bound by transcobalamin for cellular uptake. The process involves carriers like transcobalamin and haptocorrin, with transcobalamin facilitating B12's participation in metabolic reactions.
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