Psychedelics and Their Mechanisms

Classic psychedelics, such as psilocybin, LSD, and mescaline, exert their effects primarily through the serotonin 5-HT2A receptors, influencing mood and cognitive functions. These substances can produce significant perceptual alterations and emotional states, often allowing individuals to experience increased feelings of connectedness and joy. Research suggests that the effects of these psychedelics can have long-lasting positive outcomes on mental well-being, potentially persisting even a year post-experience. However, it is essential to recognize that adverse experiences, such as challenging emotions and ego dissolution, may also occur during psychedelic use.