In this insightful discussion, Richard Faragher, a professor of biogerontology at the University of Brighton, shares his expertise on the biology of aging. He explores the evolutionary mechanisms that shape our lifespans and the fascinating link between aging and diseases. Faragher delves into innovative interventions to slow aging and emphasizes the significance of lifestyle choices in extending life. With a blend of humor and science, he raises thought-provoking questions on how society might adapt to an aging population.
Aging is characterized by biological hallmarks like cell senescence and genomic instability, which contribute to increased disease likelihood over time.
Theories such as mutation accumulation and disposable soma explain aging's evolutionary significance, prioritizing reproduction over long-term somatic maintenance.
Deep dives
Understanding Aging Mechanisms
Aging is a complex biological process characterized by intrinsic mortality, which significantly increases the likelihood of diseases as one ages. Researchers identify 'aging hallmarks' such as cell senescence and genomic instability that contribute to the biological aging process. For instance, as cells divide, the protective telomeres at the end of chromosomes shorten, which is a hallmark of aging leading to cellular dysfunction. Understanding these mechanisms allows scientists to examine potential interventions to slow down aging and improve overall health in later years.
The Evolutionary Perspective on Aging
From an evolutionary standpoint, aging may seem paradoxical, but theories such as mutation accumulation and antagonistic pleiotropy explain why it occurs. These theories suggest that detrimental genetic traits can persist if they do not affect reproduction in early life, thereby allowing those traits to accumulate in populations. Additionally, the disposable soma theory posits that organisms prioritize reproduction over maintenance, as the high rates of extrinsic mortality in nature do not favor long lifespans. Consequently, these evolutionary pressures shape the way different species age and their overall longevity.
Targeting Aging as a Disease
There is a growing discourse around whether aging itself should be classified and treated as a disease, given its underlying mechanisms that cause age-related conditions. The similarities between the physiological processes driving aging and those involved in traditional diseases prompt the argument that we should focus on underlying causes rather than merely managing symptoms. Scientists are actively researching ways to delay aging, aiming to extend not just lifespan but also healthspan, ensuring more quality years without illness. This evolving approach signals a paradigm shift in how aging is perceived and treated in medical research.
Humans have always been obsessed with getting old, or rather staying young, but now science is beginning to catch up. Longevity has become a hot topic, from university laboratories to Silicon Valley startups. In the first of a Science Weekly three-part miniseries on ageing, Ian Sample speaks to Richard Faragher, a professor of biogerontology at the University of Brighton, to discover what we know about the biological hallmarks of ageing in our bodies –and why we have evolved to have the lifespans we do. Help support our independent journalism at theguardian.com/sciencepod
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