JAMA Clinical Reviews
Ulcerative Colitis: Diagnosis, Treatment, and Management
Sep 12, 2023
Gilaad Kaplan, University of Calgary, discusses the latest information on ulcerative colitis including diagnostic tests, extra intestinal manifestations, skin conditions, treatment options, health maintenance needs, vaccine safety, prognosis, and life expectancy.
15:20
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Quick takeaways
- The prevalence of ulcerative colitis is estimated to be about 400 per 100,000 people, affecting approximately 1.5 million people currently.
- Topical therapies like 5-aminosalicylic acid (5-ASA) are often used for mild to moderate ulcerative colitis, while advanced therapies like biologics and oral small molecules are available as first-line options for moderate to severe cases.
Deep dives
Epidemiology of Ulcerative Colitis
Ulcerative colitis is a bowel inflammation disorder with an incidence of roughly 15 per 100,000 people per year in North America. The prevalence in 2023 is estimated to be about 400 per 100,000 people, affecting approximately 1.5 million people currently. Diagnosis is typically based on symptoms like rectal bleeding, diarrhea, and bowel urgency, with additional diagnostic tests such as fecal calprotectin, stool cultures, and sigmoidoscopy or colonoscopy with biopsies to confirm the diagnosis.
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