NEJM This Week NEJM This Week — July 31, 2025
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Jul 30, 2025 Discover the latest breakthroughs in treating myeloma and mitochondrial DNA diseases, showcasing innovative personalized medicine strategies. Dive into the urgent need for improved motor vehicle safety and learn about groundbreaking advancements in cardiac surgery. Explore the complexities of autoimmune encephalitis and the significant implications of race-based evaluations in healthcare. Additionally, uncover the recent shifts in vaccination policies and their impact on public health narratives, emphasizing the intertwining of personal health journeys and societal influences.
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MRD-Guided Myeloma Treatment Insight
- MRD testing can guide personalized, less intensive myeloma treatment choices.
- Combining MRD status with genomic risk could optimize treatment benefit in patients.
Mitochondrial Donation Advances
- Mitochondrial donation via pronuclear transfer reduces transmission of mtDNA disease.
- This intervention is viable and effective for women with pathogenic mtDNA variants.
No Transfusion Benefit from Hemodilution
- Acute normovolemic hemodilution does not reduce allogeneic red blood cell transfusion in cardiac surgery.
- It carries no increased risk of adverse events in this setting.