Dr. Adam Rutherford joins Professor Suzannah Lipscomb to discuss the Hapsburgs' inbreeding, including their distinctive jaw and physiological challenges. They explore genetics, inbreeding, tracing ancestry, and the troubled life of Carlos II, the last ruler of the Habsburg dynasty.
The Habsburgs' deliberate inbreeding led to severe genetic disorders and disabilities, highlighting the consequences of extreme inbreeding.
The genetic isopoint for Europe is estimated to have occurred about a thousand years ago, making certain historical figures the ancestors of most people in Europe today.
Deep dives
The Inbreeding and Decline of the Habsburg Dynasty
In Madrid on November 1, 1700, Carlos II, the last ruling Habsburg, died childless, leading to the Spanish Wars of Succession. Carlos II was profoundly disabled physically and mentally, with the distinctive Habsburg jaw. This jaw, a result of generations of inbreeding, was considered a symbol of their divine right to rule. The Habsburgs engaged in deliberate inbreeding, with uncles marrying nieces, resulting in severe pedigree collapse. Charles II's family tree is a complex web of loops, where he had fewer ancestors than typical, leading to increased infant mortality and a higher chance of genetic disorders. His inbreeding coefficient was calculated to be higher than that of siblings having a child together, and his disabilities were attributed to these high levels of inbreeding.
The Genetic Isopoint and Our Shared Ancestors
The genetic isopoint is the time in history when the population at that time is the ancestor of everyone alive today. It is based on the concept that everyone has two parents, and as you go back through the generations, the number of ancestors doubles. Research suggests that the genetic isopoint for Europe occurred about a thousand years ago. This means that if anyone alive a thousand years ago has living descendants today, they are the ancestor of everyone alive today in Europe. For example, Charlemagne, the first Holy Roman Emperor, is estimated to have living descendants, making him the ancestor of most people in Europe.
The Inbreeding Coefficient and the Impact of Genetics on History
The inbreeding coefficient measures how similar an individual's genes are from their mother and father. A higher inbreeding coefficient indicates a higher similarity of genes, increasing the risk of genetic disorders. The case of Carlos II of Spain highlights the disastrous consequences of extreme inbreeding. The intention was to strengthen the power of the Habsburgs by marrying within the family, but it ultimately weakened the family and led to Charles's physical and mental disabilities. This biological component of history underscores the importance of genetics and biology in shaping historical events and reminds us of the impact biology can have on the world stage.
The Biological Component in History and Lessons Learned
The biological component of history is often overlooked or minimized, yet it plays a significant role in shaping historical events. The recent COVID-19 pandemic serves as a reminder of how pandemics have been critical historical events. Understanding the genetics and biology behind historical events can provide valuable insights and help us address and prepare for future challenges. Acknowledging the role of biology in history can deepen our understanding of past events and inform our decisions in the present and future.
One of Early Modern Europe’s most powerful families, the Habsburgs shared a physical trait so distinctive that it came to be regarded as a badge of honour - the large, jutting jaw that was a result of family inbreeding. But that was only part of their physiological challenges.
In this episode of Not Just the Tudors, Professor Suzannah Lipscomb talks about genetics, inbreeding and the sad fate of the Habsburgs with Dr. Adam Rutherford, author of A Brief History of Everyone Who Ever Lived: The Stories in Our Genes.
This episode was produced by Rob Weinberg.
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