In this podcast episode, Dr. Evie Marcolini addresses the management of elevated Intra Cranial Pressure (ICP) in diverse medical scenarios, particularly in emergency departments. She emphasizes understanding the mechanisms and effective treatments for conditions like Traumatic Brain Injury (TBI), Intracerebral Hemorrhage, and Subarachnoid Hemorrhage. Dr. Marcolini outlines a tiered approach to managing ICP, starting with simple measures such as elevating the head of the bed, administering Fentanyl for analgesia, and employing Osmotic Therapy with Mannitol or Hypertonic Saline. She delves into more invasive options like Ventriculostomy and Inodilators for severe cases while cautioning against therapeutic hypothermia. Overall, the episode provides valuable insights into ICP management strategies, encouraging healthcare professionals to consider the specific mechanisms of each case.