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Business Trip
Are psychedelics effective under anesthesia?: Boris Heifets (Stanford pt 2)
Aug 17, 2023
Boris Heifets, an assistant professor at Stanford's School of Medicine, discusses his research on the effects of ketamine on patients with depression under anesthesia. He also explores the impact of different environments on the effects of psilocybin in mice and reflects on the hype cycle of psychedelics.
37:28
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Quick takeaways
- Dissociation and acute subjective experience may not be the primary factors contributing to the therapeutic effects of ketamine on depressive symptoms.
- For psilocybin, the specific environment may have less impact on the psychedelic experience compared to other factors.
Deep dives
Ketamine Study on Anesthetized Patients with Depression
The study aimed to evaluate the effects of ketamine on anesthetized patients with depression. The researchers wanted to determine the importance of dissociation and the acute subjective experience of ketamine on the improvement of depressive symptoms. The study involved administering ketamine or a placebo to patients under general anesthesia, and the outcomes were assessed based on depression scores before and after the infusion. Surprisingly, both the ketamine and placebo groups showed a massive treatment effect of similar magnitude in terms of symptom improvement. This suggests that dissociation and acute subjective experience may not be the primary factors contributing to the therapeutic effects of ketamine.
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