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Ground Truths

Euan Ashley: Exercise may be the single most potent medical intervention ever known

Jul 5, 2024
Professor Euan Ashley discusses the groundbreaking work in human genomics and the physiologic effects of exercise from the MoTrPAC initiative. Topics include rapid whole genome sequencing, the science of exercise, targeted drug development, biologic aging, long COVID fatigue, personalized exercise routines, customized training for athletes, and the impacts of extreme exercise on heart health.
48:18

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Exercise impacts tissues like adrenal glands and immune systems, emphasizing systemic benefits.
  • Mitochondrial changes induced by exercise can mitigate liver disease and type 2 diabetes risks.

Deep dives

Motor Pack Consortium and Exercise Research

Motor Pack Consortium, a large group of principle investigators funded by the Common Fund, focused on understanding the molecular transducers of physical activity. Their exemplary studies with over 800 rats and 2400 people aimed to uncover the benefits and mechanisms of exercise on health. The consortium's research revealed significant changes in various tissues, such as a rise in immune system activation and alterations in certain tissues like the small intestine and brown adipose tissue.

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