Two Onc Docs Stem Cell Transplant (SCT) Part 1 x Dr. Jeff Auletta 2025 UPDATE
Apr 28, 2025
Joining the discussion is Dr. Jeff Auletta, a leading voice in blood and marrow transplantation. He shares insights on hematopoietic stem cell transplants, clarifying the various types and the donor matching process. The conversation dives into the risks and benefits of autologous versus allogeneic transplants, highlighting critical disparities in donor availability across ethnic groups. Dr. Auletta also emphasizes the need for systemic changes to address socio-economic barriers and ensure equitable access to transplant services for all communities.
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Stem Cell Transplant Basics
- Stem cell transplant involves giving blood-forming stem cells after a conditioning regimen to reset or replace the bone marrow.
- This can use either the patient's own cells (autologous) or another person's cells (allogeneic).
Stem Cell Collection Methods
- Hematopoietic stem cells live in bone marrow and can be collected by aspiration or mobilizing into the blood using cytokines.
- Umbilical cord blood is another source collected at birth and used as an allogeneic transplant source.
Plerixafor Mobilizes Stem Cells
- Remember that plerixafor (Poryxophor) is a CXCR4 antagonist used to mobilize stem cells into the bloodstream.
- This mechanism helps increase stem cells in peripheral blood for collection.