Mayo Clinic Talks
Osteoporosis, Fragility & Bone Health Edition | “Stiffen Up” Management of Osteoporosis
Episode guests
Podcast summary created with Snipd AI
Quick takeaways
- Bisphosphonates are considered first-line therapy for osteoporosis and work by suppressing bone breakdown, with options for oral or infusion treatment and recommended drug holidays to maintain bone resorption balance.
- Anabolic agents are a newer class of drugs that stimulate bone-building cells to work faster, and can be considered for severe osteoporosis or multiple fractures. After anabolic therapy, individuals usually transition to anti-resorptive medications to maintain bone density.
Deep dives
Goal of Osteoporosis Treatment: Preventing Fractures
The goal of treating osteoporosis is to prevent fractures and the resulting complications, such as chronic pain and disability. Treatment options like bone density tests aid in identifying those at risk, but the focus remains on avoiding fractures. Calcium and vitamin D supplements are recommended, with targets of around 1,000 milligrams of calcium per day and 20 to 25 micrograms of vitamin D. Bisphosphonates are considered first-line therapy and work by suppressing bone breakdown. They can be taken orally for five years or via infusion for three years. Drug holidays may be recommended to maintain a healthy balance in bone resorption. It is important to prioritize oral health to minimize the risk of complications such as osteonecrosis of the jaw.
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