Steve Wright: How to Retrain a Broken Gut-Immune System

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Jun 3, 2025

Steve Wright, a leading expert in gut health from The Healthy Gut Company, joins to discuss why inflammation persists despite clean eating. He explains the importance of rebuilding immune tolerance and the five gut defense layers critical for health. The conversation dives into the role of dead bacteria—para-probiotics—in retraining an overactive immune system and navigating food sensitivities. Plus, Wright shares insights on gut resilience, mitochondrial function, and innovative supplements to restore balance and well-being.

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ANECDOTE

Early Bacteria Exposure Reduces Inflammation

Early childhood exposure to dead bacteria in dirt and on farms is linked to less asthma and inflammation later in life.
Playing in dirt and being around dogs can help develop immune tolerance and reduce inflammatory diseases.

INSIGHT

Gut as Immune System Hub

70-80% of immune cells are located in and around the intestines, making the gut the central hub of immune function.
The gut immune system reaches throughout the body, linking microbiome health to overall immunity.

INSIGHT

Build Resilience Not Just Elimination

Removing toxins alone may increase reactivity; true health requires building immune resilience.
We need to move from pure elimination to creating bodies resilient to environmental stressors.

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In this episode, Dr. Jockers and Steve Wright explain why many people stay inflamed even after removing toxins and eating clean. The real issue isn’t exposure—it’s lost immune tolerance, and the solution is rebuilding resilience.

You’ll learn about the five gut defense layers that regulate your immune system. Fixing oxygen balance, mucus layers, and gut cell mitochondria is key to restoring proper function.

They also cover how para-probiotics—dead bacteria—can retrain an overactive immune response. If you’re sensitive to foods, histamines, or your environment, this episode lays out what to do next.

In This Episode:

00:00 Introduction to Early Childhood Exposure and Health Benefits
02:59 Interview with Steve Wright: Retraining a Broken Gut Immune System
05:26 Understanding the Immune System and Its Connection to the Gut
08:02 Challenges in Modern Health and the Importance of Gut Resilience
10:50 The Role of the Gut in Immune Function and Balance
23:04 Layers of the Gut and Their Functions
26:36 Mitochondria and Gut Health
27:59 Impact of Antibiotics on Gut Microbiome
28:47 The Role of Stomach Acid in Digestion
31:51 Resetting Gut Health
33:27 Individualized Diets and Food Tolerance
36:44 Repairing Gut Health: Steps and Supplements
40:32 Para Probiotics: An Overview
44:51 Healthy Gut Products and Protocols
48:46 Final Thoughts and Recommendations

Still cooking with seed oils? That could be fueling inflammation. I’ve switched to Paleovalley’s 100% grass-fed beef tallow—it’s rich in CLA, packed with flavor, and stable at high heat. It’s one of the cleanest, most nutrient-dense fats you can cook with. Head to paleovalley.com/jockers and use code JOCKERS for 15% off your order.

Heartburn doesn’t mean you have too much stomach acid—it usually means you don’t have enough. That’s why I recommend Just Thrive’s Digestive Bitters. They help ignite stomach acid, enzymes, and bile so you can finally break down food the way you’re supposed to. Go to justthrivehealth.com and use code JOCKERS to save 20%.

"Healing the gut isn’t just about avoiding toxins—it’s about building resilience."

~ Dr. Jockers

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Resources:

Get 15% off Paleovalley Beef Tallow: paleovalley.com/jockers – Use code JOCKERS
Save 20% on Just Thrive Digestive Bitters: justthrivehealth.com – Use code JOCKERS

Connect with Steve Wright:

Website: https://healthygut.com/

Connect with Dr. Jockers:

Instagram – https://www.instagram.com/drjockers/
Facebook – https://www.facebook.com/DrDavidJockers
YouTube – https://www.youtube.com/user/djockers
Website – https://drjockers.com/

If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/